Abstract Title:

Synergistic hepatoprotective effects ofω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl-induced oxidative stress-mediated liver damage in rats.

Abstract Source:

Drug Chem Toxicol. 2022 Mar 9:1-12. Epub 2022 Mar 9. PMID: 35260009

Abstract Author(s):

Sunil Chikkalakshmipura Gurumallu, Tareq Aqeel, Ashwini Bhaskar, Kannan Chandramohan, Rajesha Javaraiah

Article Affiliation:

Sunil Chikkalakshmipura Gurumallu


Flaxseed (FS) and sesame seed (SS) are traditional and functional foods in traditional Indian medicine for treating various disorders. The present study investigated the hepatoprotective effects of bioactive-fatty acids (FAs) from FS and SS against carbon tetrachloride (CCl)-induced hepatic damage in rats. Pre and post-treatments for 28 consecutive days significantly increased the activities ofantioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and peroxidase (POX), whereas, lipid peroxidation (LPO) activity was markedly decreased in a dose-dependent manner in liver and kidneys. A significant reduction was observed in the hematological parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin in the serum of post-treated animals compared to the negative control. The results were confirmed histopathologically. The results suggested that theω-3 and ω-6 FAs from flaxseed oil (FSO) and sesame seed oil (SSO), respectively, showed potential synergistic hepatoprotective and antioxidant effects that were mediated mainly by ω-3 and ω-6 FAs present in the respective seed oils.

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