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Abstract Title:

Synergistic hepatoprotective effects ofω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl-induced oxidative stress-mediated liver damage in rats.

Abstract Source:

Drug Chem Toxicol. 2022 Mar 9:1-12. Epub 2022 Mar 9. PMID: 35260009

Abstract Author(s):

Sunil Chikkalakshmipura Gurumallu, Tareq Aqeel, Ashwini Bhaskar, Kannan Chandramohan, Rajesha Javaraiah

Article Affiliation:

Sunil Chikkalakshmipura Gurumallu

Abstract:

Flaxseed (FS) and sesame seed (SS) are traditional and functional foods in traditional Indian medicine for treating various disorders. The present study investigated the hepatoprotective effects of bioactive-fatty acids (FAs) from FS and SS against carbon tetrachloride (CCl)-induced hepatic damage in rats. Pre and post-treatments for 28 consecutive days significantly increased the activities ofantioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and peroxidase (POX), whereas, lipid peroxidation (LPO) activity was markedly decreased in a dose-dependent manner in liver and kidneys. A significant reduction was observed in the hematological parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin in the serum of post-treated animals compared to the negative control. The results were confirmed histopathologically. The results suggested that theω-3 and ω-6 FAs from flaxseed oil (FSO) and sesame seed oil (SSO), respectively, showed potential synergistic hepatoprotective and antioxidant effects that were mediated mainly by ω-3 and ω-6 FAs present in the respective seed oils.

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