Abstract Title:

Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation.

Abstract Source:

J Ethnopharmacol. 2006 Nov 3;108(1):148-51. PMID: 16766151

Abstract Author(s):

Dong-Ju Son, Yong Lim, Young-Hyun Park, Sung-Keun Chang, Yeo-Pyo Yun, Jin-Tae Hong, Gary R Takeoka, Kwang-Geun Lee, Sung-Eun Lee, Mi-Ran Kim, Jeong-Han Kim, Byeoung-Soo Park

Abstract:

Full Citation: "The antiplatelet and antiproliferative activities of extract of Tabebuia impetiginosa inner bark (taheebo) were investigated using washed rabbit platelets and cultured rat aortic vascular smooth muscle cells (VSMCs) in vitro. n-Hexane, chloroform and ethyl acetate fractions showed marked and selective inhibition of platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner. These fractions, especially the chloroform fraction, also significantly suppressed AA liberation induced by collagen in [(3)H]AA-labeled rabbit platelets. The fractions, especially the chloroform fraction, potently inhibited cell proliferation and DNA synthesis induced by platelet derived growth factor (PDGF)-BB, and inhibited the levels of phosphorylated extracellular signal regulated kinase (ERK1/2) mitogen activated protein kinase (MAPK) stimulated by PDGF-BB, in the same concentration range that inhibits VSMC proliferation and DNA synthesis."

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