Abstract Title:

The anti-obesity effect of Taheebo (Tabebuia avellanedae Lorentz ex Griseb) extract in ovariectomized mice and the identification of a potential anti-obesity compound.

Abstract Source:

Biochem Biophys Res Commun. 2016 09 23 ;478(3):1136-40. Epub 2016 Aug 15. PMID: 27539320

Abstract Author(s):

Kazuko Iwamoto, Youichi Fukuda, Chisato Tokikura, Mayuko Noda, Ayami Yamamoto, Misato Yamamoto, Mitsuaki Yamashita, Nobuhiro Zaima, Akira Iida, Tatsuya Moriyama

Article Affiliation:

Kazuko Iwamoto


Estrogen deficiency-induced obesity has a high risk of visceral fat accumulation and body weight gain. It is also associated with many adverse health conditions. Taheebo extract from Tabebuia avellanedae has been recognized as playing several biological and pharmacological roles. Therefore, we investigated whether the intake of n-BuOH extract of Taheebo shows anti-obesity effect in ovariectomized (OVX) mice. After 16 weeks of feeding, the mice administrated with 0.5% n-BuOH extract of Taheebo showed significantly decreased body weight compared with that of the control mice, and the fat mass also showed a significant decrease. In 3T3-L1 cells, supplementation with n-BuOH extract of Taheebo significantly reduced the triglyceride (TG) levels. Furthermore, bioassay-guided purification of the n-BuOH extract based on the TG levels in 3T3-L1 cells led to the isolation of compound 2 (1-dehydroxy-3,4-dihydroaucubigenin). These results suggested that the anti-obesity effect of Taheebo extract is due to its capability in preventing the accumulation of adipocyte in mice. Taheebo extract might be a promising functional food resources capable of protecting against OVX-induced obesity.

Study Type : Animal Study

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