Abstract Title:

Inhibitory effect of tannic acid on gastric H+,K(+)-ATPase.

Abstract Source:

J Nat Prod. 1992 Apr;55(4):513-6. PMID: 1324983

Abstract Author(s):

S Murakami, M Muramatsu, S Otomo

Article Affiliation:

Research Center, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.


The effect of tannic acid on gastric H+,K(+)-ATPase was studied. Tannic acid dose-dependently inhibited pig gastric H+,K(+)-ATPase activity with an IC50 value of 2.9 x 10(-8) M. Tannic acid also inhibited K(+)-stimulated p-nitrophenyl phosphatase (K(+)-pNPPase) activity, which is found in gastric H+,K(+)-ATPase preparations, as well as H+,K(+)-ATPase activity, with an IC50 value of 4.1 x 10(-7) M. Kinetic studies showed that the inhibition of H+,K(+)-ATPase activity by tannic acid was competitive with respect to ATP and noncompetitive with respect to K+. These results show that tannic acid is a potent inhibitor of gastric H+,K(+)-ATPase; this may be related to its anti-secretory and anti-ulcerogenic effects.

Study Type : In Vitro Study

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