Abstract Title:

The inhibition of Candida species by selected essential oils and their synergism with amphotericin B.

Abstract Source:

Phytomedicine. 2008 Aug;15(8):635-8. Epub 2008 Jun 24. PMID: 18579358

Abstract Author(s):

Antonio Rosato, Cesare Vitali, Daniela Gallo, Luca Balenzano, Rosanna Mallamaci

Article Affiliation:

Department of Pharmaceutical Chemistry, Section of Microbiology, University of Bari, Via E. Orabona n. 4, 70125 Bari, Italy. [email protected]


In this work we highlight a possible synergistic anti-Candida effect between Melaleuca alternifolia, Origanum vulgare and Pelargonium graveolens essential oils and the antifungal compound Amphotericin B. The antifungal activity was assessed using the agar dilution method in eleven Candida strains. The results obtained indicate the occurrence of a synergistic interaction between the essential oils under study and Amphotericin B. P. graveolens essential oil appeared to be the most effective, inhibiting all the Candida species evaluated by this study.

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