Abstract Title:

Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report.

Abstract Source:

Neuropediatrics. 2013 Oct ;44(5):265-7. Epub 2013 Feb 1. PMID: 23378179

Abstract Author(s):

Chihiro Yonee, Mitsuo Toyoshima, Yoshihiro Maegaki, Yuichi Kodama, Hiroshi Hayami, Yukitoshi Takahashi, Susumu Kusunoki, Ayumi Uchibori, Atsuro Chiba, Yoshifumi Kawano

Article Affiliation:

Chihiro Yonee


INTRODUCTION: We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine.

PATIENT AND METHOD: This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular rhythm, 12 days after administration of the HPV-16/18 AS04-adjuvanted cervical cancer vaccine. After this, the patient received methylprednisolone pulse and intravenous immunoglobulin (IVIG) therapies as well as immunoadsorption plasmapheresis.

RESULTS: Severe ACA symptoms did not improve after methylprednisolone pulse and IVIG therapies, but the patient recovered completely after immunoadsorption plasmapheresis.

CONCLUSION: This temporal association strongly suggests that ACA was induced by the vaccination.

Study Type : Human: Case Report

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Sayer Ji
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