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Abstract Title:

Therapeutic efficacy of N-acetylcysteine and zinc sulphate against di-(2-ethylhexyl) phthalate-induced testicular oxido-nitrergic stress in male Wistar rat.

Abstract Source:

Andrologia. 2022 Oct ;54(9):e14508. Epub 2022 Jul 17. PMID: 35842931

Abstract Author(s):

Victor Emojevwe, Eze Kingsley Nwangwa, Alexander Obidike Naiho, Mega Obukohwo Oyovwi, Osarugue Igiehon, Eunice Ogunwole, Margaret Sope Makinde-Taylor, Oluwadamilola Ayodele Ayotomide, Adeniran Oluwadamilare Akinola, Prince Tesi Edesiri, Bright Onome Oghenetega, Simon Irikefe Ovuakporaye

Article Affiliation:

Victor Emojevwe

Abstract:

The therapeutic efficacy of N-acetylcysteine (NAC) and zinc sulphate on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular oxido-nitrergic stress in rats was investigated in 36 male Wistar rats (170 ± 10 g) randomly assigned into one of six groups (n = 6). Group 1 (control) received 2.5 ml/kg of distilled water for 42 days, while group 2 (vehicle) received 2.5 ml/kg of corn oil for 42 days. Groups 3,4,5, and 6 were administered DEHP (750 mg/kg/day) for 21 days, after which groups 4, 5, and 6 received zinc sulphate (0.5 mg/kg/day), NAC (100 mg/kg/day), and zinc sulphate (0.5 mg/kg/day) + NAC (100 mg/kg/day) for an additional 21 days respectively. After the experimental period, the animals were euthanized by light thiopental sodium, and their testes were carefully dissected out for histological and biochemical assays. The result shows a significant alteration in testicular levels of malondialdehyde, nitric oxide, antioxidant enzymes, total antioxidant capacity, sulphydryl levels, dehydrogenases and testicular architecture following the administration of DEHP. These effects were reversed by coadministration of NAC and zinc sulphate in the study. We therefore concluded that the combined effects of NAC and ZnSOeffectively improved testicular antioxidant status and reduced testicular nitregic stress, thus improving testicular architecture and functions.

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