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Article Publish Status: FREE
Abstract Title:

Therapeutic Potential and Molecular Mechanisms of Echinacoside in Neurodegenerative Diseases.

Abstract Source:

Front Pharmacol. 2022 ;13:841110. Epub 2022 Feb 4. PMID: 35185590

Abstract Author(s):

Jin Li, Hongni Yu, Chuan Yang, Tao Ma, Yuan Dai

Article Affiliation:

Jin Li

Abstract:

Echinacoside (ECH) is a natural phenylethanoid glycoside (PhG) in. A large number of studies have shown that ECH has very promising potential in the inhibition of neurodegenerative disease progression. Experimental studies strongly suggest that ECH exhibits a variety of beneficial effects associated with in neuronal function, including protecting mitochondrial function, anti-oxidative stress, anti-inflammatory, anti-endoplasmic reticulum stress (ERS), regulating autophagy and so on. The aim of this paper is to provide an extensive and actual summarization of ECH and its neuroprotective efficacy in prevention and treatment of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and so on, based on published data from bothandstudies. There is a growing evidence that ECH may serve as an efficacious and safe substance in the future to counteract neurodegenerative disease.

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