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Abstract Title:

Therapeutic potential of beta-caryophyllene against aflatoxin B1-Induced liver toxicity: biochemical and molecular insights in rats.

Abstract Source:

Chem Biol Interact. 2021 Oct 1 ;348:109635. Epub 2021 Sep 8. PMID: 34506763

Abstract Author(s):

Alice Rosa Da Silveira, Érica Vanessa Furlan Rosa, Marcel Henrique Marcondes Sari, Tuane Bazanella Sampaio, Jamila Trindade Dos Santos, Natália Silva Jardim, Sabrina Grendene Müller, Mauro Schneider Oliveira, Cristina Wayne Nogueira, Ana Flávia Furian

Article Affiliation:

Alice Rosa Da Silveira

Abstract:

Aflatoxin B(AFB) is a mycotoxin highly toxic and carcinogenic to humans due to its potential to induce oxidative stress. The Beta-caryophyllene (BCP) have been highlighted for its broad spectrum of pharmacological effects. The present study aimed to investigate the beneficial effects of BCP against the susceptibility of hepatic and renal tissues to AFBtoxicity, in biochemical parameters to assess organ function, tissue oxidation, and the immunocontent of oxidative and inflammatory proteins. Male Wistar rats was exposed to AFB(250 μg/kg, i.g.) and/or BCP (100 mg/kg, i.p.) for 14 successive days. It was found that exposure to AFBdid not change the measured renal toxicity parameters. Also, AFBincreased liver injury biomarkers (gamma glutamyl transferase and alkaline phosphatase) and reduced levels of non-enzymatic antioxidant defenses (ascorbic acid and non-protein thiol), however did not cause changes in the lipid peroxidation levels. Moreover, AFBinterfered in oxidative pathway regulated by Kelch-like ECH-associated protein (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2), overacting Glutathione-S-Transferase (GST) activity. Lastly, a main effect of AFBon the total interleukin 1 beta (IL-1β) was observed. Remarkably, the associated treatment of AFB + BCP improved altered liver parameters. In addition, BCP and AFB + BCP groups showed an increase in the levels of inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ). Thus, these results indicated that BCP has potential protective effect against AFBinduced hepatotoxicity.

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