Therapeutic potential of biochanin-A against isoproterenol-induced myocardial infarction. - GreenMedInfo Summary
Therapeutic potential of biochanin-A against isoproterenol -induced myocardial infarction in rats.
Cardiovasc Hematol Agents Med Chem. 2020 Feb 5. Epub 2020 Feb 5. PMID: 32026788
BACKGROUND: This study determined the effect of Biochanin A (BCA) on isoproterenol (ISO) induced myocardial infarction (MI) in male Wistar rats.
METHODS: Animals (Weighing 150-180 g) were divided into four groups, with six animals in each group and pretreated with BCA (10mg/kg body weight [BW] andɑ-tocopherol (60mg/kg BW for 30 days; and ISO (20mg/kg BW) was administrated subcutaneously on the day 31 and 32.
RESULTS: ISO-induced MI rats demonstrated the significant elevation of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactate dehydrogenase, creatine kinase-MB and cardiac troponin; however, concomitant pretreatment with BCA protected the rats from cardiotoxicity caused by ISO. Activities of antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase had significantly reduced in the heart with ISO-induced MI. Pretreatment with BCA produced a marked reversal of these antioxidant enzymes related to MI¬¬-induced by ISO.
CONCLUSION: In conclusion, this study suggested that BCA exerts cardioprotective effects through modulating lipid peroxidation, enhancing antioxidants, and detoxifying enzyme systems.