Abstract Title:

Therapeutic potential of naringin in neurological disorders.

Abstract Source:

Food Chem Toxicol. 2019 Jun 26 ;132:110646. Epub 2019 Jun 26. PMID: 31252025

Abstract Author(s):

Salman Ahmed, Haroon Khan, Michael Aschner, Muhammad Mohtasheemul Hasan, Sherif T S Hassan

Article Affiliation:

Salman Ahmed


Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative therapy for the treatment of various neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin and naringin (NRG) have been shown to possess promising potential in the treatment of neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and different possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.

Study Type : Review

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