The therapeutic value against acidified ethanol induced gastric and ulcer ability of M. oleifera might be due to its biocompounds. - GreenMedInfo Summary
Therapeutic strategies ofLam. (Moringaceae) for stomach and forestomach ulceration induced by HCl/EtOH in rat model.
Saudi J Biol Sci. 2022 Jun ;29(6):103284. Epub 2022 Apr 21. PMID: 35602868
Wejden Dalhoumi
Background: The drumstick treeLam. (Moringaceae), distributed in many parts of the world, is an important food plant with high nutritional value and used in medical applications and pharmaceutical industries. The aim of this study was to highlight the gastroprotective effect ofin hydrochloric acid/Ethanol (HCl/EtOH) in a rat model.
Methods: Moringa phytocompounds were characterized by infrared spectra (FTIR). Rats were induced for gastric ulcer with 150 mmol/L HCl/60% EtOH solution and pretreated orally with the edible infusion extract of the leaves ofat a single dose of 100 mg/kg body weight (bw). Antioxidant parameters and lipid peroxide levels were measured and the pathological damage was histologically analysed.
Results: The FTIR analysis showed the presence of several chemical biocompounds. The methanolic extract is the potent radical-scavengers with an estimated value of 87.54% at the higher concentration used (500 µg/ml) and antibacterial agent. Further, the DPPH inhibition value of theinfusion was 80.58%. Foranalysis, mucus was highly produced in gastric mucosa of plant-treated rats, thereby pH were elevated in rats pretreated withcompared to ulcerated animals. Whereas, lesion index was markedly reduced (79%) in stomach protected with plant. Interestingly, oral administration ofprotected gastric mucosa through decreasing MDA levels as well as increasing antioxidant enzyme activities (CAT, SOD, GPx).
Conclusion: Overall, the therapeutic value against acidified ethanol induced gastric and ulcer ability ofmight be due to its biocompounds.