Abstract Title:

Celiac disease and markers of celiac disease latency in patients with primary Sjögren's syndrome.

Abstract Source:

Am J Gastroenterol. 1999 Apr;94(4):1042-6. PMID: 10201480

Abstract Author(s):

S Iltanen, P Collin, M Korpela, K Holm, J Partanen, A Polvi, M Mäki

Article Affiliation:

Institute of Medical Technology, University of Tampere, Finland.


OBJECTIVE: Many autoimmune diseases occur concomitantly with celiac disease. We investigated prospectively the occurrence of celiac disease and small-bowel mucosal inflammation in patients with primary Sjögren's syndrome. METHODS: A total of 34 patients with primary Sjögren's syndrome and 28 controls underwent small bowel biopsy. Villous morphology, jejunal intraepithelial lymphocytes, and mucosal HLA-DR were evaluated and DQA and DQB alleles, serum antiendomysial, and antigliadin antibodies wereexamined. RESULTS: Five (14.7%) of 34 Sjögren's syndrome patients were found to have celiac disease. The density of jejunal intraepithelial gammadelta+ T cells was increased in all celiac and in four nonceliac patients. All celiac patients, 69% of nonceliac Sjögren's syndrome patients, and 11% ofcontrol subjects showed enhanced HLA-DR expression (p<0.001). HLA DQ2 was present in 19 (56%) patients with Sjögren's syndrome, including all five with celiac disease. CONCLUSIONS: The findings show a close association between Sjögren's syndrome and celiac disease. Even among nonceliac patients with primary Sjögren's syndrome, an ongoing inflammation is often present in the small bowel mucosa.

Study Type : Human Study

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