Abstract Title:

High incidence of celiac disease in patients with systemic sclerosis.

Abstract Source:

J Rheumatol. 2009 May;36(5):965-9. Epub 2009 Mar 30. PMID: 19332639

Abstract Author(s):

Edoardo Rosato, Daniela De Nitto, Carmelina Rossi, Valerio Libanori, Giuseppe Donato, Marco Di Tola, Simonetta Pisarri, Felice Salsano, Antonio Picarelli


OBJECTIVE: To evaluate the presence of celiac disease in patients with systemic sclerosis (SSc). The association of autoimmune diseases with celiac disease has been reported, but few publications deal with the combination of SSc and celiac disease. METHODS: We investigated the presence of anti-tissue transglutaminase (anti-tTG) antibodies and serum antiendomysial antibodies (anti-EMA) in 50 patients with SSc. All subjects were on a gluten-containing diet. Duodenal mucosa histology and biopsy culture were performed in anti-tTG-positive patients; anti-EMA and IgA, IgG1 anti-tTG were detected in culture supernatants. RESULTS: The incidence of celiac disease in patients with SSc was found to be 8%. Serum anti-tTG antibody-positive results were detectable in 5 out of 50 patients with SSc, but only in 4 of them was the diagnosis confirmed by histological results (Marsh classification). CONCLUSION: Our data show an increased prevalence of celiac disease in patients with SSc.

Study Type : Human Study

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