Abstract Title:

[Adrenal androgen participation in the polycystic ovary syndrome].

Abstract Source:

Rev Bras Ginecol Obstet. 2010 Nov ;32(11):541-8. PMID: 21271165

Abstract Author(s):

Angelo Barrionuevo Gil Junior, Ana Paula Rodrigues Rezende, Anselmo Verlangieri do Carmo, Erico Isaias Duarte, Márcia Marly Winck Yamamoto de Medeiros, Sebastião Freitas de Medeiros

Article Affiliation:

Médico do Hospital Universitário Júlio Müller da Universidade Federal de Mato Grosso – UFMT Cuiabá (MT), Brasil.


PURPOSE: to reassess the adrenal function of patients with PCOS after the introduction of the Rotterdam's criteria.

METHODS: descriptive and cross-sectional study including 53 patients 26 ± 5.1 years old. Glucose, glycosylated hemoglobin, lipids, estradiol, progesterone, 17-OHP4, DHEAS, FSH, LH, TSH, PRL, androstenedione, free thyroxine, insulin, total testosterone, SHBG, and free androgen index were measured. Insulin resistance was considered to be present with a homeostatic model assessment index>2.8. The adrenal response to cortrosyn was assessed by the hormonal rise observed at 60 minutes, and by the area under the response curve.

RESULTS: biochemical hyperandrogenism was found in 43 of 53 eligible patients (81.1%). Thirty-three women had adrenal hyperandrogenism (62.2%). The weight of these 33 women, aging 25.1 ± 5.0 years, was 74.9 ± 14.9 kg, BMI was 28.8 ± 6.0 and the waist/hip ratio was 0.8 ± 0.1. DHEAS was>6.7 nmol/L in 13 (39.4%) and androstenendione was>8.7 nmol/L in 31 (93.9%). The increments in 17-OHP4, cortisol, A, and progesterone were 163%, 153%, 32%, and 79%, respectively. The homeostatic insulin resistance model was>2.8 in 14 (42.4%). Insulin and estradiol were not correlated with cortisol or androgens.

CONCLUSIONS: the use of multiple endocrine parameters showed a high prevalence of biochemical hyperandrogenism in patients with PCOS. Two thirds of the patients had adrenal hyperandrogenism, and estradiol and insulin did not influence adrenal secretion.

Study Type : Human Study

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.