Abstract Title:

The association between serum vitamin Bdeficiency and tension-type headache in Turkish children.

Abstract Source:

Neurol Sci. 2018 Jun ;39(6):1009-1014. Epub 2018 Mar 8. PMID: 29520674

Abstract Author(s):

Mustafa Calik, Mehmet Salih Aktas, Emre Cecen, Ibrahim Etem Piskin, Hamza Ayaydın, Zuhal Ornek, Meryem Karaca, Abdullah Solmaz, Halil Ay

Article Affiliation:

Mustafa Calik


This study aimed to determine the relationship between serum vitamin Blevel and tension-type headache. The study groups consisted of 75 patients (40 females, 35 males) with headache and a control group of 49 healthy children (25 females, 24 males). Serum vitamin Blevel< 200 pg/ml was defined as deficient, and< 160 pg/ml as severely deficient. The serum vitamin Blevel was measured by the electrochemiluminescence (ECLIA) method. The serum vitamin Blevels in the headache and control groups were 273.01 ± 76.77 and 316.22 ± 74.53 pg/ml, with the difference determined as statistically significant (p = 0.003). In the case group, 18/75 patients (24%) had a serum vitamin B12 level below the normal of 200 pg/ml, and in the control group 4/49 (8%) patients were also below the normal range (p = 0.021). The serum vitamin Blevel in the children with tension-type headache was significantly lower than that in the control group. From the results of the study, it was concluded that there may be an association between vitamin Blevel and tension-type headache. However, further clinical studies are needed.

Study Type : Human Study

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