Abstract Title:

Protective effects of photobiomodulation against resistance exercise-induced muscle damage and inflammation in rats.

Abstract Source:

J Sports Sci. 2018 Mar 26:1-9. Epub 2018 Mar 26. PMID: 29578836

Abstract Author(s):

Helenita Antonia de Oliveira, Ednei Luiz Antonio, Flávio André Silva, Paulo de Tarso Camillo de Carvalho, Regiane Feliciano, Amanda Yoshizaki, Stella de Souza Vieira, Brunno Lemes de Melo, Ernesto Cesar Pinto Leal-Junior, Rodrigo Labat, Danilo Sales Bocalini, José Antonio Silva Junior, Paulo José Ferreira Tucci, Andrey Jorge Serra

Article Affiliation:

Helenita Antonia de Oliveira


We investigated whether low-level laser therapy (LLLT) prior to or post resistance exercise could attenuate muscle damage and inflammation. Female Wistar rats were assigned to non-LLLT or LLLT groups. An 830-nm DMC Laser Photon III was used to irradiate their hind legs with 2J, 4J, and 8J doses. Irradiations were performed prior to or post (4J) resistance exercise bouts. Resistance exercise consisted of four maximum load climbs. The load work during a resistance exercise bout was similar between Control (non-LLLT, 225 ± 10 g), 2J (215 ± 8 g), 4J (210 ± 9 g), and 8J (226 ± 9 g) groups. Prior LLLT did not induce climbing performance improvement, but exposure to 4J irradiation resulted in lower blood lactate levels post-exercise. The 4J dose decreased creatine kinase and lactic dehydrogenase levelspost-exercise regardless of the time of application. Moreover, 4-J irradiation exposure significantly attenuated tumor necrosis factor alpha, interleukin-6, interleukin-1β, cytokine-induced neutrophil chemoattractant-1, and monocyte chemoattractant protein-1. There was minor macrophage muscle infiltration in 4J-exposed rats. These data indicate that LLLT prior to or post resistance exercise can reduce muscle damage and inflammation, resulting in muscle recovery improvement. We attempted to determine an ideal LLLT dose for suitable results, wherein 4J irradiation exposure showed a significantprotective role.

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