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Abstract Title:

Influence of Crocetin, a Natural Carotenoid Dicarboxylic Acid in Saffron, on L-Type CaCurrent, Intracellular CaHandling and Contraction of Isolated Rat Cardiomyocytes.

Abstract Source:

Biol Pharm Bull. 2020 ;43(9):1367-1374. PMID: 32879211

Abstract Author(s):

Zhifeng Zhao, Bin Zheng, Jinghan Li, Ziheng Wei, Sijie Chu, Xue Han, Li Chu, Hongfang Wang, Xi Chu

Article Affiliation:

Zhifeng Zhao

Abstract:

Crocetin is a major bioactive ingredient in saffron (Crocus sativus L.) and has favorable cardiovascular effects. Here, the effects of crocetin on L-type Cacurrent (I), contractility, and the Catransients of rat cardiomyocytes, were investigated via patch-clamp technique and the Ion Optix system. A 600 µg/mL dose of crocetin decreased I31.50 ± 2.53% in normal myocytes and 35.56 ± 2.42% in ischemic myocytes, respectively. The current voltage nexus of the calcium current, the reversal of the calcium current, and the activation/deactivation of the calcium current was not changed. At 600 µg/mL, crocetin abated cell shorteningby 28.6 ± 2.31%, with a decrease in the time to 50% of the peak and a decrease in the time to 50% of the baseline. At 600 µg/mL, crocetin abated the crest value of the ephemeral Caby 31.87 ± 2.57%. The time to half maximal of Capeak and the time constant of decay of Catransient were both reduced. Our results suggest that crocetin inhibits L-type Cachannels, causing decreased intracellular Caconcentration and contractility in adult rat ventricular myocytes. These findings reveal crocetin's potential use as a calcium channel antagonist for the treatment of cardiovascular disease.

Study Type : In Vitro Study

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