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Abstract Title:

Anticonvulsive and anti-epileptogenesis effects ofroot extract, an involvement of CB2 receptor.

Abstract Source:

J Complement Integr Med. 2021 Aug 31. Epub 2021 Aug 31. PMID: 34461009

Abstract Author(s):

Masoumeh Gholami, Jamal Amri, Saeed Pazhoohan, Mehdi Sadegh

Article Affiliation:

Masoumeh Gholami

Abstract:

OBJECTIVE: Phytocannabinoids beyond theΔ9-tetrahy-drocannabinol have shown anticonvulsive effects. Also, alkylamides fromhave been proved as cannabinomimetics. We examined the effect of the hydroalcoholic root extract ofon pentylenetetrazol (PTZ)-induced tonic-clonic seizures and kindling model of epileptogenesis and the involvement of CB2 receptors as the mediator of this effect.

METHODS: Male Wistar rats (200 ± 20 g) were used. Single intraperitoneal (i.p.) injection of PTZ (80 mg/kg) was used to induce tonic-clonic seizures. The kindling model of epileptogenesis was induced by daily injections of PTZ (37 mg/kg; i.p. for 15 days). Latency and duration of the stages were monitored for analysis. The hydroalcoholic root extract ofwas injected (i.p.) 20 min before seizure induction at the doses of 10, 50, 100 and 200 mg/kg. CB2 receptor antagonist SR144528 was injected (0.1 mg/kg; i.p.) 20 min before theinjection.

RESULTS: In the tonic-clonic model, pretreatment withat the doses of 100 and 200 mg/kg significantly increased latencies to S2-S6, while it significantly decreased S6 duration and mortality rate. SR144528 injection before the injection of 100 mg/kg ofsignificantly prevented the effects of the extract on S4-S6 latencies. In the kindling model,at the doses of 100 and 200 mg/kg significantly delayed epileptogenesis and decreased mortality rate, while SR144528 injection before the injection of 100 mg/kgsignificantly blocked this effect of the extract.

CONCLUSION: These findings revealed the anticonvulsive and antiepileptogenesis effects of theroot extract, which can be mediated by CB2 receptors.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anticonvulsants : CK(678) : AC(189)

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