Abstract Title:

Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis.

Abstract Source:

Inflamm Res. 2018 Apr 23. Epub 2018 Apr 23. PMID: 29687146

Abstract Author(s):

Alyria Teixeira Dias, Sandra Bertelli Ribeiro de Castro, Caio César de Souza Alves, Marcilene Gomes Evangelista, Luan Cristian da Silva, Daniele Ribeiro de Lima Reis, Marco Antonio Machado, Maria Aparecida Juliano, Ana Paula Ferreira

Article Affiliation:

Alyria Teixeira Dias


OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction.

MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein).

TREATMENT: Genistein was used at a dose of 200 mg/kg s.c. and were initiated 2 days before the immunization and continued daily until day 6 postimmunization.

METHODS: Animals were monitored daily for clinical signs of EAE up to day 21. Inflammatory infiltration, demyelination, Toll-like receptor (TLR) expression, cytokines and transcription factors were analyzed in spinal cords.

RESULTS: The present study demonstrates, for the first time, the genistein ability to modulate the factors involved in the innate immune response in the early stages of EAE. The genistein therapy delayed the onset of the disease, with reduced inflammatory infiltration and demyelination. In addition, the expression of TLR3, TLR9 and IFN-β were increased in genistein group, with reduction in the factors of TH1 and Th17 cells.

CONCLUSION: These findings shed light on the potential of genistein as a prophylactic strategy for multiple sclerosis (MS) prevention.

Study Type : Animal Study

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