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Abstract Title:

Ginsenoside Rb1 attenuates diabetic retinopathy in streptozotocin-induced diabetic rats1.

Abstract Source:

Acta Cir Bras. 2019 Feb 28 ;34(2):e201900201. Epub 2019 Feb 28. PMID: 30843934

Abstract Author(s):

Changxia Dong, Peng Liu, Huaizhou Wang, Mei Dong, Guangxin Li, Yuanbin Li

Article Affiliation:

Changxia Dong

Abstract:

PURPOSE: To investigated the effects of ginsenoside Rb1 on diabetic retinopathy in streptozotocin-induced diabetic rats.

METHODS: Diabetes was induced by a single intraperitoneal injection of streptozotocin (80 mg/kg) in male Wistar rats. Ginsenoside Rb1 (20, 40 mg/kg) was injected (i.p.) once a day for 4 weeks. Then, using fundus photography, the diameter and vascular permeability of retinal vessels were investigated. Retinal histopathology was undertaken. Contents of malondialdehyde (MDA) and glutathione (GSH) in retinas were assayed. Levels of nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione cysteine ligase catalytic subunit (GCLC), and glutathione cysteine ligase modulatory subunit (GCLM) were measured.

RESULTS: Treatment with ginsenoside Rb1 attenuated the diabetes-induced increase in the diameter of retinal blood vessels. Ginsenoside Rb1 reduced extravasation of Evans Blue dye from retinal blood vessels. Ginsenoside Rb1 partially inhibited the increase in MDA content and decrease in GSH level in rat retinas. Nrf2 levels in the nuclei of retinal cells and expression of GCLC and GCLM were increased significantly in rats treated with ginsenoside Rb1.

CONCLUSION: These findings suggest that ginsenoside Rb1 can attenuate diabetic retinopathy by regulating the antioxidative function in rat retinas.

Study Type : Animal Study

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Sayer Ji
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