Article Publish Status: FREE
Abstract Title:

Seed Extract Alleviates Scopolamine-Induced Learning and Memory Impairment in Mice.

Abstract Source:

Front Pharmacol. 2018 ;9:389. Epub 2018 Apr 24. PMID: 29740317

Abstract Author(s):

Juan Zhou, Wu-Shuang Yang, Da-Qin Suo, Ying Li, Lu Peng, Lan-Xi Xu, Kai-Yue Zeng, Tong Ren, Ying Wang, Yu Zhou, Yun Zhao, Li-Chao Yang, Xin Jin

Article Affiliation:

Juan Zhou


The extract ofseeds has been shown to possess various pharmacological properties. In the present study, we assessed the neuropharmacological effects of 70% ethanolicseed extract (MSE) on cognitive impairment caused by scopolamine injection in mice using the passive avoidance and Morris water maze (MWM) tests. MSE (250 or 500 mg/kg) was administered to mice by oral gavage for 7 or 14 days, and cognitive impairment was induced by intraperitoneal injection of scopolamine (4 mg/kg) for 1 or 6 days. Mice that received scopolamine alone showed impaired learning and memory retention and considerably decreased cholinergic system reactivity and neurogenesis in the hippocampus. MSE pretreatment significantly ameliorated scopolamine-induced cognitive impairment and enhanced cholinergic system reactivity and neurogenesis in the hippocampus. Additionally, the protein expressions of phosphorylated Akt, ERK1/2, and CREB in the hippocampus were significantly decreased by scopolamine, but these decreases were reversed by MSE treatment. These results suggest that MSE-induced ameliorative cognitive effects are mediated by enhancement of the cholinergic neurotransmission system and neurogenesis via activation of the Akt, ERK1/2, and CREB signaling pathways. These findings suggest that MSE could be a potent neuropharmacological drug against amnesia, and its mechanism might be modulation of cholinergic activity via the Akt, ERK1/2, and CREB signaling pathways.

Study Type : Animal Study

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