Abstract Title:

Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats.

Abstract Source:

Int J Food Sci Nutr. 2019 Mar 20:1-12. Epub 2019 Mar 20. PMID: 30892114

Abstract Author(s):

Rafael Fernández-Demeneghi, Juan-Francisco Rodríguez-Landa, Rosa-Isela Guzmán-Gerónimo, Héctor-Gabriel Acosta-Mesa, Enrique Meza-Alvarado, Isidro Vargas-Moreno, Socorro Herrera-Meza

Article Affiliation:

Rafael Fernández-Demeneghi


The present study evaluated the effects of blackberry juice that is rich in different concentrations of anthocyanins and polyphenols (2.6 mg/kg anthocyanins, 14.57 mg/kg polyphenols; 5.83 mg/kg anthocyanins, 27.10 mg/kg polyphenols; 10.57 mg/kg anthocyanins, 38.40 mg/kg polyphenols) on anxiety-like behaviour in Wistar rats. The rats were treated with blackberry juice for 21 days and then tested in the elevated plus maze,locomotor activity test and forced swim test. The results were compared with a reference anxiolytic drug diazepam (2.0 mg/kg) and vehicle (8.7 ml/kg). The intermediate dose of blackberry juice exerted an anxiolytic-like effect that was similar to diazepam, without affecting locomotive activity.The low and high doses of blackberry juice exerted no significant effects on anxiety-like behaviour compared with vehicle. In the forced swim test, both the high and intermediate doses of blackberry juice reduced total immobility time, suggesting a protective effect against behavioural changes thatare induced by acute stress. These findings suggest a potential therapeutic effect of blackberry juice on anxiety that is associated with a stressful event.

Study Type : Animal Study

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