Article Publish Status: FREE
Abstract Title:

Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model.

Abstract Source:

Front Physiol. 2019 ;10:1152. Epub 2019 Sep 18. PMID: 31620010

Abstract Author(s):

Sujuan Ding, Yong Ma, Gang Liu, Wenxin Yan, Hongmei Jiang, Jun Fang

Article Affiliation:

Sujuan Ding


The aim of this study was to examine the effects ofon the microbial community and serum metabolome in colitis induced by dextran sulfate sodium (DSS). ICR mice were randomly distributed into three treatment groups: (i)treatment alone (control), (ii) DSS administration alone, and (iii) treatment withand DSS. Our results demonstrate thattreatment significantly alleviated DSS-induced body weight loss and colon inflammation. In addition, LC-MS analysis of serum metabolites revealed thattreatment increased the serum level of metabolites against inflammatory responses or oxidative stressors caused by DSS in the murine model. By detecting colonic microbiota,increased colonic microbial diversity after challenging with DSS, and increased the relative abundance of Alloprevotella at genus, but Bacteroidales was reduced (<0.05). These result indicated thatcould lower the severity of colitis induced by DSS via improving reprogramming the serum metabolome and intestinal microbiota. These findings suggest that the probioticmay prevent tissue damage from colitis.

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