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Abstract Title:

Therapeutic Benefits of Pomegranate Flower Extract: A Novel Effect That Reduces Oxidative Stress and Significantly Improves Diastolic Relaxation in Hyperglycemic In Vitro in Rats.

Abstract Source:

Evid Based Complement Alternat Med. 2022 ;2022:4158762. Epub 2022 Jun 8. PMID: 35722136

Abstract Author(s):

Yuanyuan Wei, Ahmad Taha Khalaf, Peng Ye, Wei Fan, Junyi Su, Wanlu Chen, Hao Hu, Rashid Menhas, Lifeng Wang, Zahraa Oglah

Article Affiliation:

Yuanyuan Wei

Abstract:

The pomegranate flower is an ancient herb in traditional Chinese medicine with multiple properties. Recent studies have shown that pomegranate flower extract is beneficial, especially for hyperglycemia. In this experiment, we investigated the diastolic effect of pomegranate flower polyphenol (PFP) extract on the isolated thoracic aorta of rats in both the absence and presence of high glucose levels. Isotonic contractile forces were recorded from aortic rings (about 3 mm in length) from rats using the BL-420F Biological Function Test System. Tissues were precontracted with 60 mM KCl to obtain maximum tension under 1.0 g load for 1 hour before the balance was achieved, and the fluid was changed every 15 minutes. PFP (700 mg/L-900 mg/L) showed a concentration-dependent relaxant effect on the aortic rings; vasodilation in the endothelium-intact was significantly higher than that in the de-endothelialized segments (<0.01). The endothelium-dependent vasorelaxant effect of PFP was partially attenuated by Kchannel blockers, tetraethylammonium (TEA), glibenclamide (Glib), and BaCl, as well as L-NAME (eNOS inhibitor) on the denuded endothelium artery ring. Concentration-dependent inhibition of PFP on releasing intracellular Cain the Ca-free solution and vasoconstriction of CaClin Ca-free buffer plus K(60 mM) was observed. In addition, PFP (0.1-10 mg/L) showed significant inhibition of acetylcholine-induced endothelial-dependent relaxation in the aorta of rats in the presence of high glucose (44 mmol/L). Nevertheless, the vasodilating effect of PFP was inhibited by atropine and L-NAME. The results indicated that PFP-induced vasodilation was most likely related to the antioxidant effects through enhanced NO synthesis, as well as the blocking of Kchannels and inhibition of extracellular Caentry. In conclusion, these observations showed that PFP ameliorates vasodilation in hyperglycemic rats. Hence, our results suggest that PFP supplementation may be beneficial for hypertensive patients with diabetes.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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