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Abstract Title:

Zataria multiflora affects clinical symptoms, oxidative stress and cytokines in asthmatic patient: A randomized, double blind, placebo-controlled, phase II clinical trial.

Abstract Source:

Cytokine. 2020 Sep ;133:155169. Epub 2020 Jun 22. PMID: 32585581

Abstract Author(s):

Azam Alavinezhad, Vahideh Ghorani, Omid Rajabi, Mohammad Hossein Boskabady

Article Affiliation:

Azam Alavinezhad

Abstract:

BACKGROUND: Z. multiflora effect on clinical symptoms, pulmonary function tests (PFT), oxidative stress and cytokine levels in asthmatic patients were evaluated.

METHODS: 36 asthmatic patients were divided to; placebo group (P), two groups treated with Z. multiflora extract (5 and 10 mg/kg/day, as Z5 and Z10, respectively), (n = 12 in each group). Medications were administered three times a day for two months and several parameters were evaluated before treatment (step 0), one (step 1) and two months (step 2) after treatment.

RESULTS: Clinical symptoms and PFTs were significantly improved in Z5 and Z10 groups in steps 1 and 2 compared to step 0 (p < 0.05 to p < 0.001). Improvement of oxidative stress, cytokines levels and their gene expression after treatment with both doses of extract were observed in step 2 compared to step 0 (p < 0.05 to p < 0.001).

CONCLUSION: These results indicated therapeutic value of Z. multiflora for the management of asthma.

Study Type : Human Study
Additional Links
Pharmacological Actions : Anti-Asthmatic Agents : CK(24) : AC(3)

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