Article Publish Status: FREE
Abstract Title:

Beneficial Effects of Fractions of Nardostachys jatamansi on Lipopolysaccharide-Induced Inflammatory Response.

Abstract Source:

Evid Based Complement Alternat Med. 2014 ;2014:837835. Epub 2014 Mar 30. PMID: 24795771

Abstract Author(s):

Gi-Sang Bae, Kwang-Ho Heo, Sun Bok Choi, Il-Joo Jo, Dong-Goo Kim, Joon-Yeon Shin, Seung-Hee Seo, Kyoung-Chel Park, Dong-Sung Lee, Hyuncheol Oh, Youn-Chul Kim, Ho-Joon Song, Byung-Cheul Shin, Sung-Joo Park

Article Affiliation:

Gi-Sang Bae

Abstract:

It has been previously shown that Nardostachys jatamansi (NJ) exhibits anti-inflammatory properties against lipopolysaccharide (LPS) challenges. However, the potency of NJ constituents against LPS-induced inflammatory responses has not been examined. In this present study, we determined which NJ extract fractions exhibit inhibitory effects against LPS-induced inflammatory responses. Among the NJ fractions, NJ-1, NJ-3, NJ-4, and NJ-6 inhibited LPS-induced production of NO. The NJ-3, NJ-4, and NJ-6 fractions also inhibited the production of cytokines, such as IL-1β , IL-6, and TNF- α . However, NJ-1, NJ-3, NJ-4, and NJ-6 showed differential inhibitory mechanisms against LPS-induced inflammatory responses. NJ-1, NJ-3, and NJ-4 inhibited LPS-induced activation of c-jun NH2-terminal kinase (JNK) and p38 but did not affect activation of extracellular signal-regulated kinase (ERK) or NF- κ B. On the other hand, NJ-6 inhibited activation of MAPKs and NF- κ B. In addition, in vivo experiments revealed that administration of NJ-1, NJ-3, NJ-4, and NJ-6 reduced LPS-induced endotoxin shock, with NJ-6 especially showing a marked protective effect. Taken together, these results provide the evidence for the potential of selective NJ fractions against LPS-induced inflammation. Thus, it will be advantageous to further isolate and determine single effective compounds from these potent fractions.

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Sayer Ji
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