Article Publish Status: FREE
Abstract Title:

The Effects of Mentha× piperita Essential Oil onGrowth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes.

Abstract Source:

Antibiotics (Basel). 2019 Jan 30 ;8(1). Epub 2019 Jan 30. PMID: 30704020

Abstract Author(s):

Chahrazed Benzaid, Amine Belmadani, Ryad Djeribi, Mahmoud Rouabhia

Article Affiliation:

Chahrazed Benzaid


The rise in resistance and changes in the spectrum ofinfections have generated enormous interest in developing new antifungal drugs using natural molecules such as plant essential oils (EOs). Antimicrobial activity against foodborne pathogenic and spoilage microorganisms has been reported for EOs. The goal of this study was to assess the effect of Mentha× piperita essential oil (EO) ongrowth, transition (change from blastospore to hyphae forms), and biofilm formation as well as on the expression of certain virulent genes. We show that whole EO and its vapor attenuated the yeast's growth, compared to that in the control. The effect of the EO was comparable to that of amphotericin-B (AmB). The EO and its vapor significantly decreased the morphological changes of, reduced biofilm formation, and disrupted maturebiofilms. The effect produced by whole EO on biofilm formation/disruption was notably comparable to that observed with AmB. Exposure ofto EO and its vapor downregulated the expression of various genes, such as secreted aspartyl proteinases (,,,,) and hyphal wall protein 1 (). Altogether, these results provide new insight into the efficacy of Mentha× piperita EO againstand suggest the potential of Mentha× piperita EO for use as an antifungal therapy in multiple applications.

Study Type : In Vitro Study

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