Abstract Title:

Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells.

Abstract Source:

Nutr Cancer. 2014 ;66(8):1304-14. Epub 2014 Sep 29. PMID: 25264855

Abstract Author(s):

Vy Le, Debora Esposito, Mary H Grace, Danny Ha, Anh Pham, Anthony Bortolazzo, Zackery Bevens, John Kim, Roy Okuda, Slavko Komarnytsky, Mary Ann Lila, Joseph Brandon White

Article Affiliation:

Vy Le


Walnuts contain many bioactive components that may slow cancer growth. A previous report showed that a diet supplemented with walnuts decreased the tumor size formed by MDA-MB-231 human cancer cells injected into nude mice. However, the mechanism of action was never determined. We characterized the effects of a methanol extract prepared from walnuts on human MDA-MB-231, MCF7, and HeLa cells. The extract was cytotoxic to all cancer cells. We identified compounds from the methanol extract that induced this cytotoxicity. The predominant compounds were Tellimagrandin I and Tellimagrandin II, members of the ellagitannin family. We also show a walnut extract decreases the intracellular pH, depolarizes the mitochondrial membrane with release of cytochrome c and phosphatidylserine flipping. The antimitogenic effects of walnut extract were associated with a twofold reduction of mitochondria respiration. These results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract.

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