Abstract Title:

Antifungal Effect of Magnolol and Honokiol fromonCausing Tobacco Brown Spot.

Abstract Source:

Molecules. 2019 Jun 6 ;24(11). Epub 2019 Jun 6. PMID: 31174300

Abstract Author(s):

Ya-Han Chen, Mei-Huan Lu, Dong-Sheng Guo, Ying-Yan Zhai, Dan Miao, Jian-Ying Yue, Chen-Hong Yuan, Ming-Min Zhao, De-Rong An

Article Affiliation:

Ya-Han Chen


In this study, two phenol compounds, magnolol and honokiol, were extracted fromand identified by LC-MS,H- andC-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic fungi, including(Fr.) Keissl,(Link) Thom,f.sp. solani,J. Sheld,Schltdl.,Miyabe&G. Yamada, andJ.G. Kühn, with growth inhibition of more than 57%. We also investigated the mechanisms underlying the potential antifungal activity of magnolol and honokiol. The results showed that they inhibited the growth ofin a dose-dependent manner. Moreover, magnolol and honokiol treatment resulted in distorted mycelia and increased the cell membrane permeability of, as determined by conductivity measurements. These results suggest that magnolol and honokiol are potential antifungal agents for application against plant fungal diseases.

Study Type : Plant Study

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