Antifungal Effect of Magnolol and Honokiol fromonCausing Tobacco Brown Spot.
Molecules. 2019 Jun 6 ;24(11). Epub 2019 Jun 6. PMID: 31174300
In this study, two phenol compounds, magnolol and honokiol, were extracted fromand identified by LC-MS,H- andC-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic fungi, including(Fr.) Keissl,(Link) Thom,f.sp. solani,J. Sheld,Schltdl.,Miyabe&G. Yamada, andJ.G. Kühn, with growth inhibition of more than 57%. We also investigated the mechanisms underlying the potential antifungal activity of magnolol and honokiol. The results showed that they inhibited the growth ofin a dose-dependent manner. Moreover, magnolol and honokiol treatment resulted in distorted mycelia and increased the cell membrane permeability of, as determined by conductivity measurements. These results suggest that magnolol and honokiol are potential antifungal agents for application against plant fungal diseases.