Abstract Title:

Thiamine treatment of chronic hepatitis B infection.

Abstract Source:

Am J Gastroenterol. 2001 Mar;96(3):864-8. PMID: 11280566

Abstract Author(s):

A E Wallace, W B Weeks

Article Affiliation:

Department of Psychiatry and Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA.


OBJECTIVE: Chronic hepatitis B is an international health concern that causes cirrhosis, hepatocellular carcinoma, liver failure, and death. Current treatment options are expensive and associated with side effects; however, indirect evidence suggests a relationship between relative thiamine deficiency and chronic hepatitis B infection. METHODS: The authors present three case studies wherein multiple crossovers of daily thiamine administration were used to evaluate a hypothesized association between thiamine treatment and aminotransferase levels. RESULTS: In each case study, thiamine administration was associated with reduction in aminotransferase levels and the fall of HBV DNA to undetectable levels. Analyses by t test demonstrated a statistically significant reduction in aminotransferase levels in all three cases. CONCLUSIONS: The relationship between thiamine administration and chronic hepatitis B infection warrants further study. If proven effective in reducing liver damage or inducing remission of the hepatitis B virus in larger trials, thiamine will offer obvious advantages over the current treatments for chronic viral hepatitis B infection.

Study Type : Human Study

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Sayer Ji
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