Abstract Title:

The Natural Substance MS-10 Improves and Prevents Menopausal Symptoms, Including Colpoxerosis, in Clinical Research.

Abstract Source:

J Med Food. 2016 Feb 5. Epub 2016 Feb 5. PMID: 26848802

Abstract Author(s):

Yoo-Hun Noh, Do-Hee Kim, Seung-Ah Lee, Xing Fu Yin, Jiae Park, Moo Yeol Lee, Won Bok Lee, Sang Hyung Lee, Jae Kwang Kim, Sung-Su Kim, Yoonhwa Jeong, Soon-Chul Myung, Tae Jin Kim, Il-Jun Kang

Article Affiliation:

Yoo-Hun Noh


Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of Cirsium japonicum var. maackii and Thymus vulgaris extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.

Study Type : Animal Study

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