Article Publish Status: FREE
Abstract Title:

Synergistic Antifungal, Allelopatic and Anti-Proliferative Potential of Salvia officinalis L., and Thymus vulgaris L. Essential Oils.

Abstract Source:

Molecules. 2018 Jan 16 ;23(1). Epub 2018 Jan 16. PMID: 29337923

Abstract Author(s):

Ersilia Alexa, Renata Maria Sumalan, Corina Danciu, Diana Obistioiu, Monica Negrea, Mariana-Atena Poiana, Cristian Rus, Isidora Radulov, Georgeta Pop, Cristina Dehelean

Article Affiliation:

Ersilia Alexa


The current study aimed to investigate the chemical composition and the synergistic potential of two essential oils (EOs), as obtained fromL. (SEO), andL. (TEO). The antifungal potential was tested in vitro against(Fg 06_17), the herbicidal effect was studied using weed seeds of(ARET),(CALB),(EGAL), but also wheat seeds (WS) of the Lovrin variety and tomato seeds Saint-Pierre of the variety. The GC-MS profile highlights that the mains compounds identified in SEO were: caryophyllene25.364%), camphene (14.139%), eucalyptol (13.902%), and-pinene (11.230%), while in TEO, the predominant phytochemicals were:-terpinene (68.415%) and-thymol (24.721%). The results indicated that the tested EOs alone as well as in combination have allelopathic effect against investigated seeds, while the synergistic effect of TEO and SEO in terms of fungal growth was demonstrated at a level of 0.06%. Thyme and sage EOs exhibited in vitro anti-proliferative activity on two melanoma cell lines, namely A375 human melanoma and B164A5 mouse melanoma alone, as well as in combination. SEO was most effective in terms of decreasing the cell viability of murine and human melanoma cell lines when compared to TEO.

Study Type : In Vitro Study

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