Article Publish Status: FREE
Abstract Title:

Thymoquinone attenuates hepatotoxicity and oxidative damage caused by diazinon: anstudy.

Abstract Source:

Res Pharm Sci. 2018 Dec ;13(6):500-508. PMID: 30607148

Abstract Author(s):

Amir Nili-Ahmadabadi, Parisa Alibolandi, Akram Ranjbar, Leila Mousavi, Hossein Nili-Ahmadabadi, Amir Larki-Harchegani, Davoud Ahmadimoghaddam, Navid Omidifar

Article Affiliation:

Amir Nili-Ahmadabadi


Thymoquinone (TQ) is the main active constituent ofseeds. The objective of this study was to explore the protective effects of TQ on diazinon (DZN)-induced liver toxicity in the mouse model. The animals were divided into five groups of 6 each and treated intraperitoneally. Group 1 received the vehicle, group 2 was given 16 mg/kg DZN, group 3 received 5 mg/kg TQ, and groups 4 and 5 were treated with 1.25 and 5 mg/kg of TQ as well as 16 mg/kg DZN, respectively. Finally, butyrylcholinesterase (BChE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) serum activity as well as nitric oxide (NO), lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol molecule (TTM), and histopathological experiments were evaluated in the liver samples. Our findings showed that DZN caused a significant increase in ALT (<0.01), AST (<0.001), ALP (<0.001) serum levels, LPO (<0.001) and NO (<0.001), the depletion of the TAC (<0.05) and TTM (<0.001), and structural changes in the liver tissue. Following TQ administration, a significant improvement was observed in the oxidative stress biomarkers in the liver tissue. In addition, our biochemical findings were correlated well to the histopathological examinations. In conclusion, the data from this study indicate that the administration of TQ may prevent liver damage by preventing free radical formation in animals exposed to DZN.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.