Abstract Title:

Long-term clinical significance of thyroid autoimmunity in children with celiac disease.

Abstract Source:

J Pediatr. 2010 Feb;156(2):292-5. Epub 2009 Oct 20. PMID: 19846116

Abstract Author(s):

Alessandra Cassio, Giampaolo Ricci, Federico Baronio, Angela Miniaci, Milva Bal, Barbara Bigucci, Veronica Conti, Alessandro Cicognani

Article Affiliation:

Department of Pediatrics, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy. [email protected]


OBJECTIVE: To evaluate the long-term outcome of thyroid function and autoimmunity in a large series of children with celiac disease.

STUDY DESIGN: This longitudinal, retrospective study (duration of follow-up, 8.9 +/- 4.0 years) was conducted at the Pediatric Department, University of Bologna, Italy. One hundred thirty-five consecutive patients diagnosed between June 1990 and December 2004 and followed on a gluten-free diet were examined. Inclusion criteria were good dietary compliance and duration of follow-up for at least 3 years.

RESULTS: Of 101 patients who never showed positive antithyroid titers during the follow-up, 86 remained euthyroid; 15 showed high thyroid-stimulating hormone values at diagnosis that normalized in 11 cases after 12 to 18 months of gluten withdrawal. Of 31 patients with persistently positive antibody titers, 23 (74%) remained consistently euthyroid during the follow-up and 8 (26%) had a subclinical hypothyroidism. The prevalence of cases with positive antibodies was similar in children with growth retardation or gastroenterological symptoms at diagnosis and different durations of gluten exposure.

CONCLUSIONS: The presence of antithyroid antibodies in children with celiac disease has a low predictive value for the development of thyroid hypofunction during the indicated surveillance period. Longer follow-up is needed.

Study Type : Human Study

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