n/a
Article Publish Status: FREE
Abstract Title:

Oolong Tea Extracts Alleviate Behavioral Abnormalities by Modulating Neuroinflammation in APP/PS1 Mouse Model of Alzheimer's Disease.

Abstract Source:

Foods. 2021 Dec 29 ;11(1). Epub 2021 Dec 29. PMID: 35010207

Abstract Author(s):

Hyunuk Kang, Hui Zhou, Yushan Ye, Jiangfan Yang, Zhonghua Liu, Puming He, Bo Li, Yuanyuan Wu, Yaomin Wang, Youying Tu

Article Affiliation:

Hyunuk Kang

Abstract:

Alzheimer's disease (AD) is a common neurodegenerative disease; tea components have important neuroprotective effects. This article explores the effects and mechanisms of Qingxiang(Tgy-Q), Nongxiang(Tgy-N), and Chenxiang(Tgy-C) extracts on APP/PS1 AD model mice. Morris water maze and new object recognition experiments show thatextracts can effectively enhance the cognitive ability of APP/PS1 mice. H&E staining, Nissl staining, and immunohistochemical staining show thatextracts make nerve cell boundaries and nucleoli become clearer, relieve nucleus pyknosis, and effectively reduce Aβ1-40 and Aβ1-42 in the hippocampus and cortex. They also restore the morphology of microglia and astrocytes. In addition,extracts can balance the oxidative stress level in the brain of APP/PS1 mice by improving the antioxidant capacity. Western blot results show thatextracts can reduce the expression of NF-κB p65, TNF-α, IL-1β, IL-6, COX-2, and iNOS in mouse brain, which demonstrates thatextracts improves cognitive ability by alleviating inflammation. This article demonstrates for the first time thatextracts can inhibit the excessive activation of the NF-κB p65 signaling pathway and improve the antioxidant capacity in the cerebral cortex and hippocampus, to improve the cognitive ability of APP/PS1 mice. Our results shed light into the beneficial oftea extracts on preventing and alleviating AD diseases.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.