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Abstract Title:

and Arabinogalactan in combination modulates benzo(a)pyrene-induced genotoxicity during lung carcinogenesis.

Abstract Source:

Drug Chem Toxicol. 2021 Oct 28:1-5. Epub 2021 Oct 28. PMID: 34711124

Abstract Author(s):

Yongli Chang, Diancui Zhang, Junxia Cui, Anshoo Malhotra

Article Affiliation:

Yongli Chang

Abstract:

The present study explored the effects of combination ofandon surface membrane dynamics and programmed cell deaths in rat model of lung cancer. The rats were divided into different groups namely normal control, benzo(a)pyrene (BP) treated, BP + Tinospora cordifolia (TC)-treated, BP +(A)-treated and BP + TC + A-treated groups. Significant changes were observed in the membrane dynamics of rats treated with BP. The carcinogen treatment demonstrated a marked decrease in membrane microviscosity. Also, excimer/monomer ratio and fluidity parameters of BP treated rats showed significant rise. Onthe other hand, combination ofandimprovised surface membrane dynamics. Moreover, micronuclei formation along with protein expression of bcl-2 showed significant increase in the lungs of BP treated rats. The combined treatment ofandmoderated the micronuclei formation in BP treated rats. Also, the combined treatment regulated the protein expressions of bcl-2 in BP-treated rats. As a result, marked improvement was noticed in apoptosis of BP treated cells treated with combination treatment. This study concludes that theandin combination improve the surface membrane dynamics and apoptosis in BP-treated rats.

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