Abstract Title:

α-Tocopherol Reduces Morphological Changes and Oxidative Stress during Gentamicin-Induced Acute Renal Failure.

Abstract Source:

Bull Exp Biol Med. 2018 Mar 3. Epub 2018 Mar 3. PMID: 29500805

Abstract Author(s):

N Stojiljkovic, S Ilic, M Veljkovic, J Todorovic, M Mladenovic

Article Affiliation:

N Stojiljkovic


We studied the effect ofα-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane and tubules. Combined treatment with α-tocopherol (100 mg/kg) and gentamicin (100 mg/kg) led to correction of histopathological and biochemical changes and oxidative injury to the kidneys induced by this antibiotic.

Study Type : Animal Study

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