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Article Publish Status: FREE
Abstract Title:

The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines.

Abstract Source:

Nutrients. 2019 Nov 17 ;11(11). Epub 2019 Nov 17. PMID: 31744219

Abstract Author(s):

Paola Ghanem, Annalise Zouein, Maya Mohamad, Mohammad H Hodroj, Tony Haykal, Sonia Abou Najem, Hassan Y Naim, Sandra Rizk

Article Affiliation:

Paola Ghanem

Abstract:

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects ofγ-tocotrienol, on AML cell lines. For this purpose, AML cell lines incubated withγ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway.

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