Abstract Title:

Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake.

Abstract Source:

Cell Metab. 2017 Aug 1 ;26(2):279-280. PMID: 28768164

Abstract Author(s):

Qiao-Ping Wang, Stephen J Simpson, Herbert Herzog, G Gregory Neely

Article Affiliation:

Qiao-Ping Wang


Despite widespread consumption of non-nutritive sweeteners (NNSs), the impact of manipulating the perceived sweetness of food is unclear. Previously we reported that chronic consumption of the NNSs sucralose or L-glucose led to increased calories consumed post-exposure; however, a recent study suggested this effect occurs because NNSs acutely suppress food intake, leading to a caloric debt. Here we show that acute ingestion of sucralose in the context of a low-carbohydrate diet causes a pronounced increase in calories consumed. Moreover, neither sucralose nor L-glucose had a lasting effect on food intake during chronic exposure; however, both NNSs enhance food intake post-exposure. Together these data confirm that sucralose and L-glucose promote food intake under a variety of experimental conditions.

Study Type : Commentary
Additional Links
Problem Substances : Sucrose : CK(48) : AC(12)

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