Article Publish Status: FREE
Abstract Title:

Triclosan promotes epicutaneous sensitization to peanut in mice.

Abstract Source:

Clin Transl Allergy. 2016 ;6:13. Epub 2016 Apr 5. PMID: 27051518

Abstract Author(s):

Steven Tobar, Leticia Tordesillas, M Cecilia Berin

Article Affiliation:

Steven Tobar


BACKGROUND: Peanut allergy is increasing in prevalence due to unknown factors. A growing body of clinical evidence suggests sensitization to peanut occurs through the skin, supported by findings in mouse models. There is a need to identify environmental factors that promote epicutaneous sensitization to peanut. Triclosan is an antimicrobial found in household products that has been associated with food sensitization in humans. We tested the impact of triclosan on epicutaneous sensitization to peanut, as well as the milk allergenα-lactalbumin (ALA).

RESULTS: We observed that topical triclosan promoted epicutaneous sensitization to both peanut and ALA, and promoted anaphylaxis to peanut.

CONCLUSIONS: Our results demonstrate that the mouse model of epicutaneous sensitization to foods is effective for demonstrating the clinically significant impact of environmental factors such as triclosan on food allergy.

Study Type : Animal Study
Additional Links
Problem Substances : Triclosan : CK(157) : AC(45)

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