Total flavone of Ginkgo biloba delays cell aging by inhibiting the P16 gene expression. - GreenMedInfo Summary

Abstract Title:

[Experimental study on effect of total flavone of Ginkgo biloba on delaying cell senescence].

Abstract Source:

Zhong Yao Cai. 2009 Jan;32(1):100-2. PMID: 19445133

Abstract Author(s):

Xiao-ping Song, Zhi-wu Chen, An-ning Fang, Pei-fei Fang

Article Affiliation:

Department of Biology, Anhui Medical College, Hefei 230061, China. [email protected]

Abstract:

OBJECTIVE: To investigate the mechanism of delaying the senescence of human diploid fibroblast (2BS) by total flavone of Ginkgo biloba (FG).

METHODS: The drug sera of FG was used to treat the 2BS. The population doublings of 2BS cells were observed, the mRNA expression of P16 gene was determined by fluorescence real-time quantitative PCR.

RESULTS: FG significantly extended the population doublings of 2BS cells, and decreased the expression of P16 mRNA.

CONCLUSION: FG can delay the senescence of cells by inhibiting the P16 gene expression.

Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba : CK(2047) : AC(658)
Diseases : Aging : CK(6228) : AC(1515)
Pharmacological Actions : Antioxidants : CK(34697) : AC(14549), Cell cycle arrest : CK(2126) : AC(1720), Cyclin-Dependent Kinase Inhibitor : CK(3) : AC(3), Cyclin-Dependent Kinase Inhibitor: P16 : CK(2) : AC(2)

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Key Research Topics

Substance

Ginkgo biloba

Disease

Aging

Pharmacological Actions

Antioxidants
Cell cycle arrest
Cyclin-Dependent Kinase Inhibitor
Cyclin-Dependent Kinase Inhibitor: P16

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