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Abstract Title:

Traditional Patchouli essential oil modulates the host's immune responses and gut microbiota and exhibits potent anti-cancer effects in Apcmice.

Abstract Source:

Pharmacol Res. 2022 02 ;176:106082. Epub 2022 Jan 13. PMID: 35032662

Abstract Author(s):

Waikit Leong, Guoxin Huang, Weilin Liao, Wenrui Xia, Xiaoang Li, Ziren Su, Liang Liu, Qiang Wu, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Chenglai Xia, Xiaoling Guo, Imran Khan, W L Wendy Hsiao

Article Affiliation:

Waikit Leong

Abstract:

Patchouli Essential Oil (PEO) has been used as a scent for various healing purposes since the ancient Egyptian period. The primary source of the oil is Pogostemon cablin (PC), a medicinal plant for treating gastrointestinal symptoms. However, the pharmacological function has not been addressed. Here, we report the cancer prevention and gut microbiota (GM) modulating property of PEO and its derivatives patchouli alcohol (PA) and pogostone (PO) in the Apccolorectal cancer mice model. We found that PEO, PA, and PO significantly reduced the tumor burden. At the same time, it strengthened the epithelial barrier, evidenced by substantially increasing the number of the goblet and Paneth cells and upregulation of tight junction and adhesion molecules. In addition, PEO, PA, and PO shifted M1 to M2 macrophage phenotypes and remodeled the inflammatory milieu of Apcmice. We also found suppression of CD4CD25and stimulation CD4CD8cells in the spleen, blood, mesenteric lymph nodes (MLNs), and Peyer's patches (PPs) of the treated mice. The composition of the gut microbiome of the drug-treated mice was distinct from the control mice. The drugs stimulated the short-chain fatty acids (SCFAs)-producers and the key SCFA-sensing receptors (GPR41, GPR43, and GPR109a). The activation of SCFAs/GPSs also triggered the alterations of PPAR-γ, PYY, and HSDCs signaling mediators in the treated mice. Our work showed that PEO and its derivatives exert potent anti-cancer effects by modulating gut microbiota and improving the intestinal microenvironment of the ApcMmice.

Study Type : Animal Study

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