Abstract Title:

Influence of preoperative transarterial chemoembolization on the prognosis for patients with resectable hepatocellular carcinoma: a meta-analysis of randomized trials.

Abstract Source:

Hepatogastroenterology. 2011 May-Jun;58(107-108):869-74. PMID: 21830407

Abstract Author(s):

Xiaofei Wang, Jingdong Li, Yong Peng, Yi Dai, Wei Xu

Article Affiliation:

Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.


BACKGROUND/AIMS: The efficacy of preoperative transarterial chemoembolization (TACE) for patients with resectable hepatocellular carcinoma (HCC) remains controversial. This study aims to systematically identify and summarize the effect of preoperative TACE for patients with resectable HCC.

METHODOLOGY: Databases, reference lists and conference proceedings were searched extensively to identify relevant randomized controlled trials. Data were synthesized using the random effects model. Results were expressed as hazard ratio (HR) with 95% confidence intervals (CI).

RESULTS: A total of 3 randomized controlled trials involving 257 participants were included. Meta-analysis showed that 5-year overall survival (hazard ratio 0.73, 95% CI 0.23-2.34; p=0.60) and disease-free survival (hazard ratio 1.08, 95% CI 0.66-1.77; p=0.77) had no significant differences.

CONCLUSIONS: The present data suggests that there are no significant benefits for 5-year overall survival and disease-free survival of patients with resectable HCC using preoperative TACE treatment. Further well-designed randomized controlled trials are needed to confirm or adjust current conclusions.

Study Type : Meta Analysis

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.