Abstract Title:

Transgenerational Bisphenol A causes deficits in social recognition and alters post-synaptic density genes in mice.

Abstract Source:

Endocrinology. 2019 Jun 12. Epub 2019 Jun 12. PMID: 31188430

Abstract Author(s):

Jennifer T Wolstenholme, Zuzana Drobn√°, Anne D Henriksen, Jessica A Goldsby, Rachel Stevenson, Joshua W Irvin, Jodi A Flaws, Emilie F Rissman

Article Affiliation:

Jennifer T Wolstenholme


Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical (EDC). Developmental exposure produces changes in behavior and gene expression in brain. Here we examined social recognition behaviors in mice, three generations (F3) after exposure to gestational BPA. Second generation mice were bred in one of four mating combinations to reveal whether characteristics in F3 were acquired via maternal or paternal exposures. After repeated habituation to the same mouse, offspring of dams from the BPA-lineage failed to display increased investigation of a novel mouse. Genes involved in excitatory post-synaptic densities (PSD) were examined in F3 brains using qPCR. Differential expression of genes important for function and stability of PSDs were assessed at three developmental ages. Several related PSD genes - SH3 and multiple ankyrin repeat domains 1 (Shank1), Homer scaffolding protein 1c (Homer1c), DLG associated protein 1 (Gkap), and discs large MAGUK scaffold protein 4 (PSD95) - were differentially expressed in control- versus BPA-lineage brains. Using a second strain of F3 inbred mice exposed to BPA, we noted the same differences in Shank1 and PSD95 expression found in C57BL/6J mice. In sum, transgenerational BPA exposure disrupted social interactions in mice and dysregulated normal expression of PSD genes during neural development. The fact that the same genetic effects were found in two different mouse strains and in several brain regions, increased potential for translation. The genetic and functional relationship between PSD and abnormal neurobehavioral disorders is well established and our data suggest that BPA may contribute, in a transgenerational manner, to neurodevelopmental diseases.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.