n/a
Article Publish Status: FREE
Abstract Title:

Intra-Articular Route for the System of Molecules 14G1862 from: Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis.

Abstract Source:

Nutrients. 2020 May 31 ;12(6). Epub 2020 May 31. PMID: 32486519

Abstract Author(s):

Laura Micheli, Lorenzo Di Cesare Mannelli, Luisa Mattoli, Sara Tamimi, Enrico Flamini, Stefano Garetto, Jacopo Lucci, Emiliano Giovagnoni, Lorenzo Cinci, Mario D'Ambrosio, Cristina Luceri, Carla Ghelardini

Article Affiliation:

Laura Micheli

Abstract:

Current pharmacological therapies for the management of chronic articular diseases are far from being satisfactory, so new strategies need to be investigated. We tested the intra-articular pain relieving properties of a system of molecules from a characterizedextract (14G1862) in a rat model of osteoarthritis induced by monoiodoacetate (MIA). 14G1862 (0.2-2 mg mL) was intra-articularly (i.a.) injected 7 days after MIA, behavioural and histological evaluations were performed 14, 30 and 60 days after treatments. Moreover, the effect of 14G1862 on nitrate production and iNOS expression in RAW 264.7 macrophages stimulated with LPS was assessed., 14G1862 treatment attenuated LPS-induced NO production and iNOS expression in a comparable manner to celecoxib., 14G1862 significantly reduced mechanical allodynia and hyperalgesia, spontaneous pain and motor alterations starting on day 14 up to day 60. The efficacy was higher or comparable to that evoked by triamcinolone acetonide (100μg i.a.) used as reference drug. Histological evaluation highlighted the improvement of several morphological parameters in MIA + 14G1862-treated animals with particularly benefic effects on joint space and fibrin deposition. In conclusion, i.a. treatment withis a candidate to be a novel effective approach for osteoarthritis therapy.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.