Abstract Title:

Prescript-assist probiotic-prebiotic treatment for irritable bowel syndrome: an open-label, partially controlled, 1-year extension of a previously published controlled clinical trial.

Abstract Source:

Clin Ther. 2007 Jun;29(6):1153-60. PMID: 17692729

Abstract Author(s):

Alvah C Bittner, Robert M Croffut, Mary C Stranahan, Titut N Yokelson

Abstract:

OBJECTIVE: The aim of this study was to extend a previous 2-week assessment of a probiotic-prebiotic complex in patients with irritable bowel syndrome (IBS). METHODS: In this open-label, partially controlled, 1-year (14 [2] months) extension study, data were collected from patients with IBS who continued treatment following a 2-week study of the efficacy of the probiotic-prebiotic complex. Data were collected at 2 and approximately 60 weeks after the end of the original study. RESULTS: A total of 25 patients entered the 2-week extension and 22 completed the approximately 60-week follow-up study (20 women, 2 men; age range, 20-70 years; all white). Results in the control group 2 weeks after crossover to treatment were similar to those from the original study, with reductions in IBS subsyndromes, as follows: general ill feelings/nausea (P<0.001), indigestion/flatulence (P<0.001), and marginally colitis (P<0.03 [1-tailed]). Treatment was associated with a continued reduction in general ill feelings/nausea at 4 weeks (P<0.007). At>or=52-week follow-up, the rate of remissions was 81.5% to 100% (P<0.003). CONCLUSION: Based on the results from the present 1-year extension study, treatment with this probiotic-prebiotic complex may be an option for short-term (2-4 weeks) and long-term ( approximately 60-week) reductions in IBS symptoms.

Study Type : Human Study

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