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Article Publish Status: FREE
Abstract Title:

Treatment of radiation-induced brain injury with bisdemethoxycurcumin.

Abstract Source:

Neural Regen Res. 2023 Feb ;18(2):416-421. PMID: 35900439

Abstract Author(s):

Yun-Qian Chang, Gui-Juan Zhou, Hong-Mei Wen, Duan-Qun He, Chen-Lin Xu, Ya-Rui Chen, Yi-Hui Li, Shuang-Xi Chen, Zi-Jian Xiao, Ming Xie

Article Affiliation:

Yun-Qian Chang

Abstract:

Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500μL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury.

Study Type : Animal Study

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Sayer Ji
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