Abstract Title:

Role of Tribulus terrestris (Linn.) (Zygophyllacea) against mercuric chloride induced nephrotoxicity in mice, Mus musculus (Linn.).

Abstract Source:

J Environ Biol. 2006 May;27(2 Suppl):397-400. PMID: 17436531

Abstract Author(s):

A V Kavitha, G Jagadeesan


The present study investigates the influence of methanolic fraction (MF) of Tribulus terrestris fruit extract on the kidney tissues of mercury intoxicated mice, Mus musculus. At median-lethal dose of mercuric chloride (12.9 mg/kg body weight), the whole kidney tissue showed an increased level of lipid peroxidation (LPO), glutathione peroxidase (GPx) activities and simultaneously a decreased level of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH). These parameters reached to near normal after administration of fruit extracts of T. terrestris for 7 days. The results suggested that the oral administration of methanolic fraction of Tribulus terrestris fruit extract at dose 6 mg/kg body weight provided protection against the mercuric chloride induced toxicity in the mice.

Study Type : Animal Study

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