Abstract Title:

[Sdudy on effect of tripterygium on plasma IL-18 content in patients with lupus nephritis].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2008 May;33(9):1075-7. PMID: 18652362

Abstract Author(s):

Cai-Yun Jin, Guo-Hua Hu, Bi-Zhong Zheng, Dong-Lian Wang


OBJECTIVE: It is to study the effect of tripterygium (TW) on the plasma IL-18 content in patients with lupus nephritis (LN) and its treatment value. METHOD: The patients with LN treated with prednisone were divided into active groupand inactive group with active index. The active group was given tripterygium additionally. The changing of plasma IL-18 and release of nephritis were observed after treatment for three months. RESULT: The level of plasma IL-18 lowered down obviously, urinary protein decreased, LN activity index, hematuria and renal function improved. CONCLUSION: Tripterygium caninhibitroduction of plasma IL-18. It has definite treatment value on controlling LN activity.

Study Type : Human Study

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